Determination of Inducible Clindamycin Resistance Amongst Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Kaduna, Nigeria

For quite a long time, mainly due to fewer treatment options, Clindamycin have been regarded as an alternative drug effectively manage all Staphylococcus aureus infections. Strains with inducible clindamycin resistance (iMLSB phenotype) raise concerns because therapeutic failure may occur during treatment. is mostly in treating serious infections that cannot be treated by other antibiotics, it cause colitis or mild diarrhea. A double disc diffusion test (D-test) for detecting erythromycin-resistant methicillin-resistant S. was performed placing 15µg erythromycin proximity 2µg adjacent positions. isolates, D-test can help determine whether could used option (reported susceptible when the negative reported resistant positive). Twenty (20) out of 30 (thirty) isolates collected were confirmed determined per CLSI guidelines. Fifteen (15) Negative, 5 both Erythromycin and Clindamycin, none positive. should included mandatory method routine testing detect staphylococci optimum patients.